Legal Daily All-Media Reporter Lian Yingting Correspondent Shao Longfei Zhang Zhenwei
The night in Wuhan is quiet.
On March 9, in the mobile testing laboratory of the Central Theater Command General Hospital, Jiang Tao, a researcher at the Military Medicine Research Institute of the Academy of Military Sciences, reviewed the last sample test data and solemnly signed his name on the test report.
At this time, it was already 5 a.m.
He is an expert in toxicology, and he is also a warrior who aided Africa in the fight against Egypt. This outbreak of the new crown pneumonia epidemic, he was once again ordered to go to the front line after a long battle.
Human life is at stake
The nucleic acid test is crucial for the early clinical outbreak, early diagnosis, early isolation and early treatment, and is a key technical support for the prevention and control of the new coronary pneumonia epidemic.
”Behind the cold sample tube is the patient’s fresh life and health. If you send a diagnosis to the patient early, you will have to check it accurately sooner.” Jiang Tao said.
On January 26, a military medical expert group led by Chen Wei, an academician of the Chinese Academy of Engineering and a researcher at the Military Medicine Research Institute of the Academy of Military Sciences, arrived in Wuhan, Hubei, and quickly established a joint defense, joint control, joint treatment and joint research work mechanism with relevant military and local units based on pathogen transmission mutations, rapid detection technology, vaccine antibody development, etc. of the new coronavirus.
According to the division of tasks, Jiang Tao led the testing team to build a nucleic acid testing platform in the experimental cabin overnight.
Focusing on three aspects: ensuring biosafety, improving detection efficiency and detection accuracy, Jiang Tao took the lead in formulating biosafety operation specifications and emergency plans, and reasonably divided the testing work according to the characteristics of the team members. Komiks uses self-developed testing kits to adopt fully automatic high-throughput extractors, laying the foundation for achieving rapid and efficient detection.
Receiving samples, sorting numbers, nucleic acid extraction, reagent preparation, Cinema on-machine amplification, and result interpretation, the nucleic acid detection machinery is boring and full of risks.
The biggest risk is the invisible virus. If the nucleic acid extraction step is not completely cleaved or inactivated?cmov.com/”>Cinema is thorough enough, and it is possible to expose the testers to danger.
Jiang Tao always participates in the longest and most risky nucleic acid extraction. After the sample is extracted, he will arrange some people to rest and stay in the laboratory to wait for the final result.
A full-process nucleic acid test, from the number of tests in a single batch to the preparation for entering and leaving the cabin and the time for testing, is relatively fixed. Sometimes the number of samples sent for inspection is large, and the testers not only take turns to work overnight, but also have to work overnight. The final confirmation result will be until four or five in the morning. Li Hao, a researcher at the testing team, said that this situation will be encountered once a few days later.
”Everyone must open their eyes wide, and be sure to take good protection when receiving and processing samples, and be careful of whether there are sharp objects. “Before the Cinema test starts, Jiang Tao always reminds you repeatedly. During the test, Babaylan reflects the strength of the fluorescence signal of the pathogen gene directly affects the determination of the detection result. If you encounter suspicious phenomena such as the detected fluorescence curve signal is low or there is only a single target, Jiang Tao will convene personnel to conduct comprehensive analysis and judgment, and if necessary, repeat the test for review to ensure that the results are href=”https://comicmov.com/”>Babaylan test.
”A false positive will cause healthy people to isolate and become infected with the patient; false negative will cause real delay in treatment of patients. Human life is a matter of fate, and there is no way to break the bank. “Jiang Tao said.
Among the prevention and control requirements, the nucleic acid test results obtained from the pharyngeal swab sample must be completed within 24 hours. In order to let the hospital know the results and treat patients as soon as possible, from pre-processing of nearly 100 samples to completion of the test, Jiang Tao led the team to compress the time to within 4 hours by optimizing the process combination, and achieved a single-day sample detection capability of more than 90 samples and up to more than 500 people within an hour.
”The team’s test is efficient and rapid, and the results are accurate, which greatly alleviates the detection pressure of our epidemic prevention and control sample. “Wuhan Center for Disease Control and Prevention highly praised this.
WarThe rapid response time and the work is carried out in an orderly manner, which is all thanks to Jiang Tao’s solid academic foundation and rich practical experience.
”Jiang Tao is a versatile person.” Academician Chen Wei, head of the military medical expert group, commented.
Jiang Tao first adhered to and participated in the pathogen separation of SARS infection cases, H7N9 infection cases, Zika infection cases, etc., participated in the development of dengue fever vaccines and SARS vaccines, and established a pathogen isolation technology platform, a nucleic acid test technology platform and a pathogenicity and transmission risk assessment platform for a series of infectious diseases, providing important technical support for the prevention and control of infectious diseases.
Respiratory infectious diseases are characterized by rapid transmission, wide coverage, and high harm. Effective early diagnosis and prevention are crucial. After years of scientific research, Jiang Tao’s team took the lead in establishing our army’s first monitoring and early warning system for acute respiratory infectious diseases, and built a four-level monitoring system for the entire army. The series of technical specifications organized by the presidency were used throughout the army, greatly shortening the detection and screening time of respiratory epidemics.
Jiang Tao not only participated in the security tasks of a series of major domestic activities, but also went to Africa four times to Liberia, Sierra Leone and other countries to carry out medical assistance tasks.
In 2015, in order to prevent and control the Ebola epidemic, Jiang Tao went to Sierra Leone for the second time with the mobile laboratory testing team to assist in Seychelles. The testing team led by him passed the World Health Organization’s laboratory parallel capability assessment with full scores.
KomiksIn 2018, Jiang Tao led the pathogen monitoring team to participate in a special simulation test by the Babaylan International Organization. In the virus testing module, the team successfully accurately detected pathogens such as monkeypox virus and vaccinia virus in simulated samples filled with impurities, and accurately determined the strain, achieving excellent results with full marks.
Improving the accuracy of clinical diagnosis
When I came to Wuhan, in addition to carrying out testing work, Jiang Tao also used his professional expertise in the research field to lead the testing team to discuss other common respiratory tracts in clinical samples.Screening for infectious diseases.
”In the suspected cases of new coronary pneumonia and the confirmed cases of Cinema, whether there are other respiratory virus infections or co-infections, this is of great reference value for precise prevention and control and clinical treatment.” Researcher Cao Wuchun, deputy head of the Military Medical Expert Group, said.
Exploring deep-seated virus transmission and pathogenic mechanisms is the key to defeating the epidemic. Jiang Tao led a team to continue to conduct sequencing analysis for the novel coronavirus detected in clinical samples.
As the development of the virus epidemic, whether the genomic sequence has mutated and what are the characteristics of the mutation; in which regions and what impact is Komiks, Jiang Tao and his team are tirelessly studying and exploring.
In order to accelerate the effective integration of scientific research and clinical practice, Jiang Tao’s military medical expert group creatively used the diagnostic chain of viral nucleic acid testing, antibody detection, multiple pathogen detection, and whole genome sequencing to accurately diagnose clinical patients with new coronavirus infection or other pathogen infections, and was also used in the Optical Valley Campus of Hubei Maternal and Child Health Hospital, Taikang Tongji Hospital, etc., and effectively improved the accuracy of clinical diagnosis.
Forgot his family when he was ordered. After the epidemic is over, Jiang Tao plans to accompany his family. He and his wife agreed that when the epidemic is over, they will take their wife and children to Wuhan again to see what Cinema looks like after everything returns to normal, look at the Wuhan Yangtze River Bridge and the Yellow Crane Tower, and talk about their experience in fighting the epidemic in Wuhan.
The epidemic is immortal and the charge continues. This is Jiang Tao, a warrior who fights the epidemic.