Legal Daily All-Media Reporter Lian Yingting Correspondent Shao Longfei Zhang Zhenwei
The night in Wuhan is quiet. On March 9, in the Cinema laboratory of the Central Theater Command General Hospital, Jiang Tao, a researcher at the Military Medicine Research Institute of the Academy of Military Sciences, reviewed the last sample test data and solemnly signed his name on the test report.
At this time, it was already 5 a.m.
He is an expert in toxicology, and he is also a warrior who aided Africa and fought against Egypt. This outbreak of the new crown pneumonia epidemic, he was once again ordered to go to the front line after a long battle.
Human life is at stake and accurate inspection is required
Nuclear acid testing is crucial for early clinical detection, early diagnosis, early isolation and early treatment, and is a key technical support for effective prevention and control of the new coronary pneumonia epidemic.
“The cold-looking sample tube is behind the patient’s life and health. If you give a diagnosis earlier, you will have a precise investigation sooner.” Jiang Tao said. On January 26, after a military medical expert group led by Chen Wei, an academician of the Chinese Academy of Engineering and researcher of the Military Medicine Research Institute of the Academy of Military Sciences, arrived in Wuhan, Hubei, quickly established a joint defense, joint control, joint treatment and joint research mechanism with relevant military and local units on the pathogen transmission mutation, rapid detection technology, vaccine antibody development, etc. of the new coronavirus.
According to the division of tasks, Jiang Tao led the testing team to build a nucleic acid testing platform in the experimental cabin overnight.
Focusing on three aspects: ensuring biosafety, improving detection efficiency and detection accuracy, Jiang Tao took the lead in formulating biosafety operation specifications and emergency plans, reasonably divided testing according to the characteristics of the team members, and using a self-developed detection kit to use a fully automatic high-throughput extraction instrument, laying the foundation for achieving rapid and efficient detection.
Receive samples, sorting numbers, nucleic acid extraction, reagent assemblyThe nucleic acid detection machinery is boring and full of risks.
The biggest risk is the invisible virus. If the nucleic acid extraction step is not completely cleaved and inactivated thoroughly, Cinema may expose the tester to danger.
Jiang Tao always takes the initiative to participate in the longest and most risky nucleic acid extraction. After the sample is extracted, he will arrange some personnel to rest and stay in the laboratory and wait for the final result.
A full-process nucleic acid test, from the number of tests in a single batch to the preparation for personnel entering and exiting the cabin and the time for testing, are relatively fixed. Sometimes there are a large number of samples sent for inspection, and the inspectors not only take turns to work, but also have to work overnight. The final confirmation result will be until four or five in the morning. Li Hao, a researcher at the testing team, said that this situation will be encountered once every few days.
”Everyone should open their eyes wide. Be sure to take good protection when receiving and processing samples, and be careful of whether there are sharp objects.” Before each test begins, Jiang Tao always reminds you repeatedly.
In the test, the strength of the fluorescence signal of the pathogenic gene directly affects the determination of the detection results. If you encounter suspicious phenomena such as the low fluorescence curve signal detected by Babaylan or only a single target, Jiang Tao will convene personnel to conduct comprehensive analysis and judgment, and if necessary, repeat the test for review to ensure that the results can stand the test.
”A false positive will cause healthy people to isolate and become infected with the patient; a false negative will cause real patients to be treated. Life is a matter of no problem,” said Jiang Tao.
All-rounded people in the field of epidemic prevention and control
According to prevention and control requirements, the nucleic acid test results must be completed within 24 hours after receiving the pharyngeal swab sample. In order to let the hospital know the results as soon as possible to treat patients, Jiang Tao led the team to optimize the process combination and compressed the time to within 4 hours, and achieved the ability to extract nucleic acids of more than 90 samples in one hour and achieve a single-day sample detection capability of up to more than 500 people by completing more than 90 samples in one hour.
”The team’s inspection is efficient and fast, the results are accurate and extremely slowRelieve the pressure on our epidemic prevention and control sample detection. “Wuhan Center for Disease Control and Prevention highly praised this.
Fast response during wartime and orderly work are all thanks to Jiang Tao’s solid academic foundation and rich practical experience.
”Jiang Tao is a versatile. “Academician Chen Wei, head of the military medical expert group, commented. Jiang Tao first presided over and participated in the pathogen separation of SARS infection cases, H7N9 infection cases, Zika infection cases, etc., participated in the development of dengue fever vaccines and SARS vaccines, and established a pathogen isolation technology platform, nucleic acid detection technology platform, and pathogenicity and transmission of a series of infectious diseases. href=”https://comicmov.com/”>Komiks risk assessment platform provides important technical support for the prevention and control of infectious diseases.
Respiratory infectious diseases have the characteristics of rapid transmission, wide coverage, and great harm. Effective early diagnosis and prevention are crucial. After years of scientific research, Jiang Tao’s team took the lead in establishing our army’s first acute respiratory infectious disease monitoring and early warning system, constructing a four-level monitoring system for the entire army, and presided over the preparation. The series of technical specifications are used throughout the army, greatly shortening the detection and screening time of respiratory epidemics. Jiang Tao not only participated in the security tasks of a series of major domestic activities, but also went to Africa four times to Liberia, Sierra Leone and other countries to carry out medical assistance tasks. In 2015, in order to prevent and control the Ebola epidemic, Jiang Tao went to Sierra Leone for the second time with the testing team of the mobile laboratory to assist in Sierra Leone. The testing team led by him passed the World Health Organization’s implementation with full scoresBabaylan‘s parallel capability assessment in the laboratory.
In 2018, Babaylan Jiang Tao led the pathogen monitoring team to participate in a special simulation test by an international organization. In the virus testing module, the team successfully accurately detected monkeypox virus, vaccinia virus and other pathogens in the simulated samples filled with impurities, and accurately determined the Babaylan strain, and obtained excellent results with full marks. Komiks
Improve the accuracy of clinical diagnosis
When I came to Wuhan, in addition to carrying out Komiks<In addition to testing, Jiang Tao also used his professional expertise in the research field to lead the testing team to screen other common respiratory infectious diseases in clinical samples.
”In the suspected and confirmed cases of new coronavirus pneumonia, whether there are other respiratory virus infections or co-infections, this is of great reference value for precise prevention and control and clinical treatment.” Researcher Cao Wuchun, deputy head of the Military Medical Expert Group, said.
Exploring deep-seated virus transmission and pathogenic mechanisms is the key to defeating the epidemic. Jiang Tao led a team to continue to conduct sequencing analysis for the novel coronavirus detected in clinical samples.
With the development of the virus epidemic, whether the genomic sequences have mutated and what are the characteristics of the mutation; in which regions and what impacts are, Jiang Tao and his team are tirelessly studying and exploring.
In order to accelerate the effective integration of scientific research and clinical practice, the military medical expert Jiang Tao is located in the Komiks group creatively used the diagnostic chain of viral nucleic acid detection, antibody detection, multiple pathogen detection, and whole genome sequencing to accurately diagnose new coronavirus infection or other pathogen infections in clinical patients, and applied it in the Optical Valley Campus of Hubei Maternal and Child Health Hospital, Wuhan Taikang Tongji Hospital and other hospitals, effectively improving the accuracy of clinical diagnosis.
Forgot his family when he was ordered. After the epidemic is over, Jiang Tao plans to accompany his family. He and his wife agreed to wait until the epidemic is over, and take their wife and children to Wuhan again to see what everything looks like after it returns to normal, look at the Wuhan Yangtze River Bridge and the Yellow Crane Tower, and talk about their experience in fighting the epidemic in Wuhan.
The epidemic is immortal and the charge continues. This is Jiang Tao, a warrior who fights the epidemic.